Excess Homocysteine is proven to cause the following biochemical problems:
 

Increases levels of asymmetric dimethylarginine (ADMA) which binds to NOS genes.

ADMA interferes with L-arginine in the production of
nitric oxide (NO), a key chemical involved in normal endothelial function and, by extension, cardiovascular health. 

 

As ADMA binds to NOS genes, it shuts off Nitric Oxide production, and increases production of Peroxynitrate
– a toxic free radical
.

 

Increases neurological degeneration in brain tissue during ischemia/hypoxia/stoke events.

      
Changes firing patter of hippocampus, causes loss of hippocampus grey matter (loss of memory, dementia).


Forms chemical bonds with cysteine and other proteins thus weakening elastic connective tissues in the skin, lungs, and arterial wall; predisposes towards aortic and thoracic aneurisms.

    
Decreases choline and phospholipid levels in the cell wall, increases saturated fatty acid content of cell walls, causing increases in cholesterol in the blood stream.

 

Activates Endoplasmic Reticulum Stress (ER Stress) which causes proteins in the cell to be malformed and shaped incorrectly, decreasing cellular function and lifespan.
 

Reduces insulin sensitivity in the cell and leads to an elevated risk of Type II Diabetes.

Shrinks grey and white matter in the brain causing brain atrophy, esp. in situations like epilepsy, Parkinson’s, and Alzheimer’s


High levels of homocysteine are linked to early development of heart disease.
In fact, a high level of homocysteine is a risk factor for heart disease.
It's associated with low levels of vitamins B2, B6, B12, and Folate,




 Why Methylation is a Big Deal?



Methylation is a core process that occurs in all cells to help your body make biochemical conversions.  
The methylation process is responsible for:

 

Cellular Repair: synthesis of nucleic acids, production & repair of DNA & mRNA
 

Detoxification and Neurotransmitter Production:  interconversion of amino acids
 

Healthy Immune System Function:  formation & maturation of red blood cells,
white blood cells & platelet production.
     


MTHFR can make you susceptible to illness because

the pathway is the primary source of glutathione production in the body. 

People with MTHFR anomalies usually have low glutathione, which makes them more susceptible to stress and less tolerant to toxins. 

As we age MTHFR problems get much worse due to the accumulation of toxins and the cumulative effect of oxidative stress, which ages our bodies
.